Monitoramento das Produções

Title: ENSP cria Protocolo de monitoramento de ocorrência de Covid-19 em comunidades
Authors: Périssé, André Reynaldo Santos
Abstract: Segundo o Ministério da Saúde, os próximos dois meses podem ser cruciais para o Brasil. Isso porque o país pode vir a sofrer aumento da incidência de doenças como a Covid-19, a gripe comum e a dengue. O crescimento de casos dessas enfermidades pode elevar o número de atendimentos e internações por quadros graves, sobrecarregando o sistema de saúde. Diante desse risco provocado pela pandemia do novo coronavírus, a ENSP elaborou um Protocolo que prevê ações de monitoramento de casos leves de Covid-19 e de vigilância ativa em comunidades. Em entrevista ao Informe ENSP, o pesquisador da Escola André Périssé falou sobre o documento, que será publicado em breve.

by Michael K. McCracken, Gregory D. Gromowski, Lindsey S. Garver, Brad A. Goupil, Kathryne D. Walker, Heather Friberg, Jeffrey R. Currier, Wiriya Rutvisuttinunt, Kevin L. Hinton, Rebecca C. Christofferson, Christopher N. Mores, Yannick Vanloubbeeck, Clarisse Lorin, Marie-Pierre Malice, Stephen J. Thomas, Richard G. Jarman, David W. Vaughn, J. Robert Putnak, Lucile Warter

Dengue virus (DENV) is transmitted by infectious mosquitoes during blood-feeding via saliva containing biologically-active proteins. Here, we examined the effect of varying DENV infection modality in rhesus macaques in order to improve the DENV nonhuman primate (NHP) challenge model. NHPs were exposed to DENV-1 via subcutaneous or intradermal inoculation of virus only, intradermal inoculation of virus and salivary gland extract, or infectious mosquito feeding. The infectious mosquito feeding group exhibited delayed onset of viremia, greater viral loads, and altered clinical and immune responses compared to other groups. After 15 months, NHPs in the subcutaneous and infectious mosquito feeding groups were re-exposed to either DENV-1 or DENV-2. Viral replication and neutralizing antibody following homologous challenge were suggestive of sterilizing immunity, whereas heterologous challenge resulted in productive, yet reduced, DENV-2 replication and boosted neutralizing antibody. These results show that a more transmission-relevant exposure modality resulted in viral replication closer to that observed in humans.

Title: Bilateral median nerve neuritis after chikungunya virus infection
Authors: Rueda-Lopes, Fernanda Cristina; Soares, Cristiane N; Vieira, Iracema Forni; Mendonça, Silvana; Martins, Ezequias Batista; Lant, Suzannah; Sequeira, Patrícia C; Solomon, Tom; de Filippis, Ana Maria Bispo; Calvet, Guilherme; Brasil, Patrícia

Title: Aspectos clínicos e terapêuticos da infecção da COVID-19
Authors: Castro-de-Araujo, Luis Fernando S.; Strina, Agostino; Grassi, Maria Fernanda Rios; Teixeira, Maria Glória
Abstract: Este documento tem como propósito apresentar, de forma resumida e clara, alguns aspectos clínicos, terapêuticos e epidemiológicos sobre o novo Coronavírus (SARS-Cov-2), que produz uma doença denominada COVID-19, e vem causando uma pandemia que preocupa toda a humanidade, em função da alta transmissibilidade do seu agente, velocidade de disseminação, elevada incidência e gravidade. O objetivo é disponibilizar alguns aspectos considerados relevantes e de interesse para a população e profissionais de saúde com base nos avanços científicos que vêm sendo alcançados em todo o mundo, publicados em periódicos revisados por pares e informações de interesse oriundas de outras fontes fidedignas. Além disso, também estão incluídas orientações emanadas pelas Agências Nacionais e Internacionais de Saúde Pública.
Description: Documento reúne as principais evidências científicas sobre a Covid-19 e foi elaborado por um grupo de pesquisadores da Rede Covida – iniciativa conjunta do Centro de Integração de Dados e Conhecimentos para Saúde (Cidacs/Fiocruz Bahia) e da Universidade Federal da Bahia (UFBA).

Title: População em situação de rua em tempos de coronavírus
Abstract: Confira as orientações e recomendações do coordenador das equipes de Consultório na Rua de Niterói (RJ), Alexandre Trino, para os profissionais de saúde que trabalham com população em situação de rua.
Description: Vídeo publicado no site e nas redes sociais da Fiocruz Brasília no dia 03 de abril de 2020.

Title: Resistance of Aedes Aegypti to organophosphaes in several municipalities in the State of Rio de Janeiro and Espírito Santo, Brazil
Authors: LIma, José Bento Pereira; Cunha, Marcella Pereira da; Silva Jùnior, Ronaldo Carneiro da; Galardo, Allan Kardec Ribeiro; Soares, Sidinei da Silva; Braga, Ima Aparecida; Ramos, Ricardo Pimentel; Valle, Denise
Abstract: Chemical insecticides have been widely used in Brazil for several years. This exposes mosquito populations
to an intense selection pressure for resistance to insecticides. In 1999, the Brazilian National Health Foundation started
the first program designed to monitor the resistance of Aedes aegypti to insecticides. We analyzed populations from 10
municipalities (from 84 selected in Brazil) in the states of Rio de Janeiro and Espírito Santo. Exposure of larvae to a
diagnosticdose of temephos showed in alterations in susceptibility in all populations. Mosquitoes from eight municipalities exhibited resistance, with mortality levels ranging from 74% (Campos dos Goytacazes, Rio de Janeiro) to 23.5%
(São Gonçalo, Rio de Janeiro). The resistance ratios of mosquitoes from three municipalities ranged from 3.59 to 12.41.
Adults from only one municipality (Nova Iguaçu, Rio de Janeiro) remained susceptible to both fenitrothion and
malathion. These results are being used to define new local vector control strategies.
Description: Acesso aberto em 04/04/2020 - http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.518.9800&rep=re...

Title: Effectiveness of methoprene, an insect growth regulator, against temephos-resistant Aedes aegypti populations from different Brazilian localities, under laboratory conditions
Authors: Braga, Ima Aparecida; Mello, Cícero Brasileiro; Montella, Isabela Reis; Lima, José Bento Pereira; Júnior, Ademir de Jesus Martins; Medeiros, Priscila Fernandes Viana; Valle, Denise
Description: Disponível on line em 04/04/2020 - https://academic.oup.com/jme/article/42/5/830/863658

Title: Fiocruz lidera frentes de pesquisa de combate ao Covid-19
Authors: Barreto, Marcelo Menna
Description: Matéria jornalística publicada no "Jornal Extra Classe: Jornalismo além da superfície" no dia 03 de abril de 2020. Disponível em: https://www.extraclasse.org.br/saude/2020/04/fiocruz-lidera-todas-as-fre...

Title: Evaluation of the Persistence of Three Larvicides Used To Control Aedes aegypti In Arapiraca, Northeastern Brazil
Authors: Amorim, Quesia Santos; Bauzer, Luiz Guilherme Soares da Rocha; Aparecida Braga, Ima; Lima, José Bento Pereira

by Rezal Bohari, Chong Jin Hin, Asmad Matusop, Muhamad Rais Abdullah, Teoh Guat Ney, Seleena Benjamin, Lee Han Lim

Several sites, Z-7L, Z-5 and Z-14, in Sibu district, Sarawak, Malaysia, experienced intense dengue transmission in 2014 that continued into 2015. A pilot study with Bacillus thuringiensis israelensis (Bti) to control Aedes aegypti (L.) and Ae. albopictus (Skuse) was evaluated in Z-7L, a densely populated site of 12 ha. Bti treatments were conducted weekly from epidemiology week (EW) 24/2015 for 4 weeks, followed by fortnight treatments for 2 months, in addition to the routine control activities. Bti was directly introduced into potable containers and the outdoor artificial and natural containers were treated via a wide area spray application method using a backpack mister. Aedes indices significantly reduced during the treatment and post treatment phases, compared to the control site, Z-5 (p

by Fotios Petropoulos, Spyros Makridakis

What will be the global impact of the novel coronavirus (COVID-19)? Answering this question requires accurate forecasting the spread of confirmed cases as well as analysis of the number of deaths and recoveries. Forecasting, however, requires ample historical data. At the same time, no prediction is certain as the future rarely repeats itself in the same way as the past. Moreover, forecasts are influenced by the reliability of the data, vested interests, and what variables are being predicted. Also, psychological factors play a significant role in how people perceive and react to the danger from the disease and the fear that it may affect them personally. This paper introduces an objective approach to predicting the continuation of the COVID-19 using a simple, but powerful method to do so. Assuming that the data used is reliable and that the future will continue to follow the past pattern of the disease, our forecasts suggest a continuing increase in the confirmed COVID-19 cases with sizable associated uncertainty. The risks are far from symmetric as underestimating its spread like a pandemic and not doing enough to contain it is much more severe than overspending and being over careful when it will not be needed. This paper describes the timeline of a live forecasting exercise with massive potential implications for planning and decision making and provides objective forecasts for the confirmed cases of COVID-19.

by Cleo Anastassopoulou, Lucia Russo, Athanasios Tsakris, Constantinos Siettos

Since the first suspected case of coronavirus disease-2019 (COVID-19) on December 1st, 2019, in Wuhan, Hubei Province, China, a total of 40,235 confirmed cases and 909 deaths have been reported in China up to February 10, 2020, evoking fear locally and internationally. Here, based on the publicly available epidemiological data for Hubei, China from January 11 to February 10, 2020, we provide estimates of the main epidemiological parameters. In particular, we provide an estimation of the case fatality and case recovery ratios, along with their 90% confidence intervals as the outbreak evolves. On the basis of a Susceptible-Infectious-Recovered-Dead (SIDR) model, we provide estimations of the basic reproduction number (R0), and the per day infection mortality and recovery rates. By calibrating the parameters of the SIRD model to the reported data, we also attempt to forecast the evolution of the outbreak at the epicenter three weeks ahead, i.e. until February 29. As the number of infected individuals, especially of those with asymptomatic or mild courses, is suspected to be much higher than the official numbers, which can be considered only as a subset of the actual numbers of infected and recovered cases in the total population, we have repeated the calculations under a second scenario that considers twenty times the number of confirmed infected cases and forty times the number of recovered, leaving the number of deaths unchanged. Based on the reported data, the expected value of R0 as computed considering the period from the 11th of January until the 18th of January, using the official counts of confirmed cases was found to be ∼4.6, while the one computed under the second scenario was found to be ∼3.2. Thus, based on the SIRD simulations, the estimated average value of R0 was found to be ∼2.6 based on confirmed cases and ∼2 based on the second scenario. Our forecasting flashes a note of caution for the presently unfolding outbreak in China. Based on the official counts for confirmed cases, the simulations suggest that the cumulative number of infected could reach 180,000 (with a lower bound of 45,000) by February 29. Regarding the number of deaths, simulations forecast that on the basis of the up to the 10th of February reported data, the death toll might exceed 2,700 (as a lower bound) by February 29. Our analysis further reveals a significant decline of the case fatality ratio from January 26 to which various factors may have contributed, such as the severe control measures taken in Hubei, China (e.g. quarantine and hospitalization of infected individuals), but mainly because of the fact that the actual cumulative numbers of infected and recovered cases in the population most likely are much higher than the reported ones. Thus, in a scenario where we have taken twenty times the confirmed number of infected and forty times the confirmed number of recovered cases, the case fatality ratio is around ∼0.15% in the total population. Importantly, based on this scenario, simulations suggest a slow down of the outbreak in Hubei at the end of February.

Title: Multi-epitope based vaccine against yellow fever virus applying immunoinformatics approaches
Authors: Tosta, Stephane Fraga de Oliveira; Passos, Mariana Santana; Kato, Rodrigo; Salgado, Álvaro; Xavier, Joilson; Jaiswal, Arun Kumar; Soares, Siomar C.; Azevedo, Vasco; Giovanetti, Marta; Tiwari, Sandeep; Alcantara, Luiz Carlos Junior

Title: Identification of Zika virus in immature phases of Aedes aegypti and Aedes albopictus: a surveillance strategy for outbreak anticipation
Authors: Maniero, V. C.; Rangel, P. S. C.; Coelho, L. M. C.; Silva, C. S. B.; Aguiar, R. S.; Lamas, C. C.; Cardozo, S. V.

Title: Podcast Viralizados: quanto tempo o novo Coronavírus sobrevive no ambiente?
Abstract: Quais são os sintomas da Covid-19? Por quanto tempo o novo coronavírus sobrevive no ambiente? O médico epidemiologista e pesquisador Cláudio Maierovitch, da Fiocruz Brasília, responde. O Viralizados é uma produção da Fiocruz Brasília sobre temas que estão em destaque na mídia e na sociedade.
Description: Podcast publicado em 25 de março de 2020 pela Fiocruz Brasília.

Title: Acesso e acolhimento na APS com enfoque no enfrentamento ao COVID 19
Abstract: Este vídeo é uma das atividades do conjunto de debates do Programa de Residência em Gestão Políticas Públicas da Saúde e o Programa de Residência Multiprofissional em Atenção Básica com o intuito de auxiliar os profissionais residentes e os profissionais de saúde com informações para o enfrentamento da Pandemia do COVID-19. A atividade contou com a presença de Claudio Maierovitch, médico sanitarista, coordenador e pesquisador do Núcleo de Epidemiologia e Vigilância em Saúde (Nevs) da Fiocruz Brasília, Mariana Pastorello Verotti pesquisadora e professora da Escola Fiocruz de Governo da Fiocruz Brasília e a Doutora Aclair.
Description: Vídeo publicado no dia 26 de março de 2020 no site da Fiocruz Brasília.

Title: Conexão Fiocruz Brasília: o novo Coronavírus e nossa saúde mental
Abstract: Em meio à pandemia mundial do novo coronavírus e dos relatos de populações que viveram semanas de isolamento social evitando aglomerações e contendo o avanço da Covid-19, surgiu a preocupação de como cuidar da saúde mental em um momento como este? O Conexão Fiocruz Brasília apresentou no dia 26/3/2020 o tema “O novo coronavírus e a nossa saúde mental”, ao vivo nas redes sociais com uma introdução da pesquisadora e diretora da Fiocruz Brasília Fabiana Damásio, moderação do debate Wagner Vasconcelos pesquisador e coordenador da Assessoria de Comunicação da Fiocruz Brasília e como palestrantes a Debora Noal pesquisadora e sanitarista da Fiocruz, que possuí uma vasta experiência em estudos no cuidado com pessoas vivendo situações de desastres e epidemias, a Karine Dutra psicóloga e pesquisadora do grupo de pesquisa em saúde mental da Fiocruz Brasília, Helenice Macedo e Jozilda Oliveira Brasileiro enfermeiras da Secretaria de Saúde de Distrito Federal.
Description: 2º Conexão Fiocruz Brasília exibido ao vivo no site e nas redes sociais da Fiocruz Brasília no dia 27 de março de 2020.

by Rattanam AhbiRami, Wan Fatma Zuharah

The massive flood in Malaysia’s east coast in December 2014 has placed Kelantan in a possible dengue outbreak risk. At this point, community awareness is essential in preventing disease spread. However, no data on knowledge, attitude, and practice (KAP) of dengue in Kelantan have existed in relevance to flood disaster, although such information is necessary for the vector control programs. The purpose of this study is to assess the KAP regarding dengue among school children from flooded and unflooded areas and to evaluate the effectiveness of the dengue health education program in improving their KAP level. A school-based pre- and post-tests design was utilized in this study whereby a booklet on dengue was distributed during the interphase of the tests. The information collected was on the socio-demographic, KAP and the source of dengue information. We statistically compared the KAP between the two study sites and the pre- and post-test scores to evaluate the health education program. A total of 203 students participated in the survey, and 51.7% of them were flood victims. When comparing the baseline KAP, the respondents from the unflooded area had higher knowledge scores compared to those from the flooded area (P0.05). The health education program significantly improved knowledge and practice in the flooded area and knowledge only in the unflooded area (P

Title: O novo coronavírus e a nossa saúde mental
Abstract: Conexão Fiocruz Brasília aborda os cuidados da saúde mental em meio à pandemia do novo Coronavírus. Evitar o consumo de tabaco, álcool e drogas lícitas e ilícitas são algumas orientações para cuidar da saúde mental durante o isolamento social. A pesquisadora do Centro de Estudos e Pesquisas em Emergências e Desastres em Saúde (Cepedes) da Fiocruz, Débora Noal, alerta ainda para o contexto vivido pelos profissionais de saúde em meio a pandemia, que resulta em demonstrações de medo, confusão, agitação desordenada, irritação e aumento de conflitos entre membros da equipe, reforçando ainda a presença de equipes de saúde mental nesses ambientes. “Nosso trabalho enquanto equipe de saúde é, sim, isolar o vírus, mas de forma alguma isolar o afeto humano”.
Description: O novo Coronavírus e a nossa saúde mental - Débora Noal; Este vídeo faz parte de uma série criada pelo Conexão Fiocruz Brasília com o foco nos cuidados com a saúde mental no enfrentamento da Pandemia do COVID-19.; Este vídeo foi publicado no site da Fiocruz Brasília no dia 24 de março de 2020.

Title: Detection of Yellow Fever Virus by Quantitative Real-Time PCR (qPCR)
Authors: Trindade, Gisela Freitas; Lima, Sheila Maria Barbosa de; Britto, Constança; Fernandes-Monteiro, Alice Gomes

Title: Forecasting dengue fever in Brazil: An assessment of climate conditions
Authors: Stolerman, Lucas M.; Maia, Pedro D.; Kutz, J. Nathan

Title: Plano de contingência do Instituto de Comunicação e Informação Científica e Tecnológica em Saúde (Icict/Fiocruz) diante da pandemia da doença pelo SARS-CoV-2 (COVID-19): versão 1, de 20 de março de 2020
Description: Inclui os Anexos: I - 10 medidas de prevenção para as bibliotecas da Fiocruz; II - Listagem dos responsáveis dos setores e e-mail.

Title: Podcast Viralizados: qual é a gravidade da Covid-19?
Abstract: O novo coronavírus ou (a doença) Covid-19 é o assunto do momento. Qual é a gravidade da Covid-19? O médico epidemiologista e pesquisador Cláudio Maierovitch, da Fiocruz Brasília, responde.
O Viralizados é uma produção da Fiocruz Brasília sobre temas que estão em destaque na mídia e na sociedade.
Description: Podcast publicado em 24 de março de 2020 pela Fiocruz Brasília.

Title: Tem alguma dúvida sobre coronavírus?
Abstract: O Coronavírus pertence a um grupo de vírus que tem em sua estrutura aparência semelhante a coroa, por isso recebeu esse nome na década de 60. O primeiro caso do vírus SARS-COV-2 foi detectado em humanos na China, em 31 de dezembro de 2019. Ele recebeu este nome SARS-COV-2 pela Organização Mundial da Saúde em fevereiro de 2020.
Description: Vídeo postado em 17 de março de 2020 pela Fiocruz Brasília.

by Edouard Hallet, Claude Flamand, Dominique Rousset, Timothée Bonifay, Camille Fritzell, Séverine Matheus, Maryvonne Dueymes, Balthazar Ntab, Mathieu Nacher
Background A recent study in French Guiana suggested that populations living in precarious neighborhoods were more at risk for Chikungunya CHIKV than those living in more privileged areas. The objective of the present study was to test the hypothesis that Zika virus (ZIKV) infection was more frequent in precarious pregnant women than in non-precarious pregnant women, as reflected by their health insurance status. Methods A multicentric cross-sectional study was conducted in Cayenne hospital including ZIKV pregnant women with serological or molecular proof of ZIKV during their pregnancy between January and December 2016. Health insurance information was recorded at delivery, which allowed separating women in: undocumented foreigners, precarious but with residence permit, and non-precarious. Results A total of 6654 women were included. Among them 1509 (22,7%) had confirmed ZIKV infection. Most women were precarious (2275/3439) but the proportion of precarious women was significantly greater in ZIKV-confirmed 728/906 (80.4%) than the ZIKV-negatives 1747/2533 (69.0%), p

by Basile Kamgang, Marie Vazeille, Armel Tedjou, Aurélie P. Yougang, Theodel A. Wilson-Bahun, Laurence Mousson, Charles S. Wondji, Anna-Bella Failloux

Zika virus (ZIKV) is a Flavivirus (Flaviviridae) transmitted to humans mainly by the bite of an infected Aedes mosquitoes. Aedes aegypti is the primary epidemic vector of ZIKV and Ae. albopictus, the secondary one. However, the epidemiological role of both Aedes species in Central Africa where Ae. albopictus was recently introduced is poorly characterized. Field-collected strains of Ae. aegypti and Ae. albopictus from different ecological settings in Central Africa were experimentally infected with a ZIKV strain isolated in West Africa. Mosquitoes were analysed at 14- and 21-days post-exposure. Both Ae. aegypti and Ae. albopictus were able to transmit ZIKV but with higher overall transmission efficiency for Ae. aegypti (57.9%) compared to Ae. albopictus (41.5%). In addition, disseminated infection and transmission rates for both Ae. aegypti and Ae. albopictus varied significantly according to the location where they were sampled from. We conclude that both Ae. aegypti and Ae. albopictus are able to transmit ZIKV and may intervene as active Zika vectors in Central Africa. These findings could contribute to a better understanding of the epidemiological transmission of ZIKV in Central Africa and develop suitable strategy to prevent major ZIKV outbreaks in this region.

by Uzma Shahid, Joveria Q. Farooqi, Kelli L. Barr, S. Faisal Mahmood, Bushra Jamil, Kehkashan Imitaz, Zahida Azizullah, Faisal R. Malik, Dhani Prakoso, Maureen T. Long, Erum Khan
Background Arboviruses are a cause of acute febrile illness and outbreaks worldwide. Recent outbreaks of Chikungunya virus (CHIKV) in dengue endemic areas have alarmed clinicians as unique clinical features differentiating CHIKV from Dengue virus (DENV) are limited. This has complicated diagnostic efforts especially in resource limited countries where lab testing is not easily available. Therefore, it is essential to analyse and compare clinical features of laboratory confirmed cases to assist clinicians in suspecting possible CHIKV infection at time of clinical presentation. Methodology A prospective point prevalence study was conducted, with the hypothesis that not all patients presenting with clinical suspicion of dengue infections at local hospitals are suffering from dengue and that other arboviruses such as Chikungunya, West Nile viruses, Japanese Encephalitis virus and Zika virus are co-circulating in the Sindh region of Pakistan. Out-patients and hospitalized (in-patients) of selected district hospitals in different parts of Sindh province of Pakistan were recruited. Patients with presumptive dengue like illness (Syndromic diagnosis) by the treating physicians were enrolled between 2015 and 2017.Current study is a subset of larger study mentioned above. Here-in we compared laboratory confirmed cases of CHIKV and DENV to assess clinical features and laboratory findings that may help differentiate CHIKV from DENV infection at the time of clinical presentation. Results Ninety-eight (n = 98) cases tested positive for CHIKV, by IgM and PCR and these were selected for comparative analysis with DENV confirmed cases (n = 171). On multivariable analysis, presence of musculoskeletal [OR = 2.5 (95% CI:1.6–4.0)] and neurological symptoms [OR = 4.4 (95% CI:1.9–10.2)], and thrombocytosis [OR = 2.2 (95% CI:1.1–4.0)] were associated with CHIKV infection, while atypical lymphocytes [OR = 8.3 (95% CI:4.2–16.7)] and thrombocytopenia [OR = 8.1 (95% CI:1.7–38.8)] were associated with DENV cases at time of presentation. These findings may help clinicians in differentiating CHIKV from DENV infection. Conclusion CHIKV is an important cause of illness amongst patients presenting with acute febrile illness in Sindh region of Pakistan. Arthralgia and encephalitis at time of presentation among patients with dengue-like illness should prompt suspicion of CHIKV infection, and laboratory confirmation must be sought.

Title: Covid-19: Cartaz de recomendação do teste para diagnóstico
Abstract: A Fiocruz tem produzido uma série de materiais informativos sobre a pandemia da doença pelo SARS-CoV-2 (Covid-19). A reprodução do material é livre e gratuita. Baixe e compartilhe informação correta e de qualidade.

Title: Covid-19: Fiocruz contra as Fake News
Abstract: A Fiocruz tem produzido uma série de materiais informativos sobre a pandemia da doença pelo SARS-CoV-2 (Covid-19). A reprodução do material é livre e gratuita. Baixe e compartilhe informação correta e de qualidade.

by Mingli Yuan, Wen Yin, Zhaowu Tao, Weijun Tan, Yi Hu

Radiologic characteristics of 2019 novel coronavirus (2019-nCoV) infected pneumonia (NCIP) which had not been fully understood are especially important for diagnosing and predicting prognosis. We retrospective studied 27 consecutive patients who were confirmed NCIP, the clinical characteristics and CT image findings were collected, and the association of radiologic findings with mortality of patients was evaluated. 27 patients included 12 men and 15 women, with median age of 60 years (IQR 47–69). 17 patients discharged in recovered condition and 10 patients died in hospital. The median age of mortality group was higher compared to survival group (68 (IQR 63–73) vs 55 (IQR 35–60), P = 0.003). The comorbidity rate in mortality group was significantly higher than in survival group (80% vs 29%, P = 0.018). The predominant CT characteristics consisted of ground glass opacity (67%), bilateral sides involved (86%), both peripheral and central distribution (74%), and lower zone involvement (96%). The median CT score of mortality group was higher compared to survival group (30 (IQR 7–13) vs 12 (IQR 11–43), P = 0.021), with more frequency of consolidation (40% vs 6%, P = 0.047) and air bronchogram (60% vs 12%, P = 0.025). An optimal cutoff value of a CT score of 24.5 had a sensitivity of 85.6% and a specificity of 84.5% for the prediction of mortality. 2019-nCoV was more likely to infect elderly people with chronic comorbidities. CT findings of NCIP were featured by predominant ground glass opacities mixed with consolidations, mainly peripheral or combined peripheral and central distributions, bilateral and lower lung zones being mostly involved. A simple CT scoring method was capable to predict mortality.